Plinest One 4ml

Plinest One 4ml is a next-generation polynucleotide biostimulator from Mastelli, presented in a larger volume format for extensive skin rejuvenation. It delivers highly purified polynucleotides in a 4ml vial, allowing practitioners to treat larger surface areas or multiple regions in one session. Plinest One is designed for deep skin hydration, improved elasticity, and structural dermal rejuvenation across the face and body. Its mechanism involves stimulating fibroblasts to increase collagen and elastin synthesis, thereby strengthening the dermal matrix and improving skin density. This treatment is especially useful for areas with noticeable volume loss or laxity (such as the cheeks, neck, arms, or abdomen) where broad biostimulation is needed. With Plinest One, patients can achieve enhanced tissue quality, better skin tone, and reduced signs of aging over large areas, with results that are long-lasting (approximately 6 months, varying by individual). 

Contains

• Polynucleotides (PN-HPT) – formulated at ~2 mg/ml concentration in a 4 ml vial (total of ~8 mg PN per vial), providing a gentle yet effective stimulus for collagen production over a wide area
  
• (This product does not contain hyaluronic acid; it is a pure polynucleotide gel optimized for large-area diffusion and biostimulation. Each box comes with 5 vials of 4ml, facilitating full treatment courses.)
  

Intended for

• Large treatment zones requiring rejuvenation – e.g. full face and neck, or neck and upper chest, or arms and hands – making it ideal for patients with widespread sun damage or laxity who wish to improve skin quality uniformly
  
• Visible volume loss or crepey skin on the body (such as upper arms with “crepe” skin, abdomen after weight loss, or thighs) where enhancing dermal thickness and elasticity can lead to firmer, smoother skin
  
• Mature skin with multiple aging signs (dullness, fine lines, sagging) that would benefit from a comprehensive biostimulation approach rather than localized filler – Plinest One treats the cause (collagen depletion) over a broad area rather than just filling wrinkles
  
• Adjunct to aesthetic procedures: can be used to prepare the skin before a major procedure (like laser therapy) or as a restorative treatment afterward, to accelerate healing and amplify overall results by improving the regenerative capacity of the skin